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Comparative Study
. 1989;99(3):386-8.
doi: 10.1007/BF00445563.

A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors

G H Bone  1 , E Majchrowicz, P R Martin, M Linnoila, D J Nutt
Affiliations
Comparative Study

A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors

G H Bone et al. Psychopharmacology (Berl). 1989.

Abstract

The calcium antagonists nimodipine and dantrolene were compared with diazepam in an animal model of tolerance and physical dependence upon ethanol. Nimodipine and dantrolene were both effective in suppressing withdrawal tremors but diazepam was clearly superior to both agents. These results suggest that the ethanol withdrawal syndrome is only partially mediated by increased calcium flux.

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