Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 May;94(18):e867.
doi: 10.1097/MD.0000000000000867.

Incidence and risk factors for retinopathy of prematurity in multiple gestations: a Chinese population study

Gordon S K Yau  1 , Jacky W Y Lee, Victor T Y Tam, Stan Yip, Edith Cheng, Catherine C L Liu, Benjamin C Y Chu, Ian Y H Wong
Affiliations

Incidence and risk factors for retinopathy of prematurity in multiple gestations: a Chinese population study

Gordon S K Yau et al. Medicine (Baltimore). 2015 May.

Abstract

To determine the incidence and risk factors of retinopathy of prematurity (ROP) among new-born Chinese infants of multiple gestations.A retrospective review of medical records was performed for all neonates of multiple gestations screened for ROP between January 2007 and December 2012 in 2 neonatal intensive care units in Hong Kong. Screening was offered to very low birth weight (VLBW; ≤1500 g) and/or preterm (gestation ≤32 weeks) neonates using the Royal College of Ophthalmologists ROP guideline and the International Classification of ROP by 3 pediatric ophthalmologists. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP.A total of 153 Chinese infants of multiple gestations were included in the study. The mean gestational age (GA) was 30.8 ± 2.4 weeks and the mean birth weight (BW) was 1284.8 ± 267.4 g. The incidence of ROP and Type 1 ROP was 11.8% and 3.9%, respectively. On univariate analysis, younger GA, lighter birth weight, postnatal hypotension, inotropes use, bronchopulmonary disease, and intraventricular hemorrhage were common independent risk factors for the development of ROP and Type 1 ROP (all P ≤ 0.04). On multivariate analysis, younger GA, surfactant use, invasive mechanical ventilation, higher mean oxygen concentration, thrombocytopenia, intraventricular hemorrhage, total parental nutrition, and hypoglycemia were significant risk factors for ROP. For Type 1 ROP, there were no significant dependent risk factors.In preterm Chinese infants born from multiple gestations, prematurity, lighter weight, postnatal hypotension, inotropes use, bronchopulmonary dysplasia, and an intraventricular hemorrhage were common independent risk factors for the development of ROP and Type 1 ROP.

PubMed Disclaimer

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of the distribution of infants belonging to multiple gestations.
See this image and copyright information in PMC

References

    1. Terry TL. Retrolental fibroplasia in premature infants. Further studies on fibrolastic overgrowth of tunica vasculosa lentis. Arch Ophthalmol 1945; 33:203–208. - PMC - PubMed
    1. Steinkuller PG, Du L, Gilbert C, et al. Childhood blindness. J AAPOS 1999; 3:26–32. - PubMed
    1. Centers for Disease Control and Prevention. Contribution of assisted reproduction technology and ovulation—inducing drugs to triplet and higher-order multiple births—United States, 1980–1997. JAMA 2000; 284:299–300. - PubMed
    1. Barr S, Poggi S, Keszler M. Triplet morbidity and mortality in a large case series. J Perinatol 2003; 23:368–371. - PubMed
    1. Oleszczuk JJ, Keith DM, Keith LG, et al. Projections of population-based twinning rates through the year 2100. J Reprod Med 1999; 44:913–921. - PubMed