OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis

D J Hunter¹, R D Altman², F Cicuttini³, M D Crema⁴, J Duryea⁵, F Eckstein⁶, A Guermazi⁷, R Kijowski⁸, T M Link⁹, J Martel-Pelletier¹⁰, C G Miller¹¹, T J Mosher¹², R E Ochoa-Albíztegui¹³, J-P Pelletier¹⁰, C Peterfy¹⁴, J-P Raynauld¹⁰, F W Roemer¹⁵, S M Totterman¹⁶, G E Gold¹⁷

Affiliations

¹ Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia; Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.
² Department of Medicine, Division of Rheumatology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
³ School of Public health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
⁴ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
⁵ Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Brazil.
⁶ Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
⁷ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
⁸ Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
⁹ Department of Radiology and Biomedical Imaging, UCSF, San Francisco, USA.
¹⁰ Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
¹¹ BioClinica, Newtown, PA, USA.
¹² Department of Radiology, Penn State University, Hershey, PA, USA; Department of Orthopaedic Surgery, Penn State University, Hershey, PA, USA.
¹³ Department of Radiology, The American British Cowdray Medical Center, Mexico City, Mexico.
¹⁴ Spire Sciences, Inc., Boca Raton, Florida, USA.
¹⁵ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
¹⁶ Qmetrics Technologies, Rochester, NY, USA.
¹⁷ Department of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

PMID: 25952343
DOI: 10.1016/j.joca.2015.03.012

Free article

Review

OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis

D J Hunter et al. Osteoarthritis Cartilage. 2015 May.

Free article

. 2015 May;23(5):698-715.

doi: 10.1016/j.joca.2015.03.012.

Authors

Affiliations

¹ Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia; Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.
² Department of Medicine, Division of Rheumatology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
³ School of Public health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
⁴ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
⁵ Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Brazil.
⁶ Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
⁷ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
⁸ Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
⁹ Department of Radiology and Biomedical Imaging, UCSF, San Francisco, USA.
¹⁰ Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
¹¹ BioClinica, Newtown, PA, USA.
¹² Department of Radiology, Penn State University, Hershey, PA, USA; Department of Orthopaedic Surgery, Penn State University, Hershey, PA, USA.
¹³ Department of Radiology, The American British Cowdray Medical Center, Mexico City, Mexico.
¹⁴ Spire Sciences, Inc., Boca Raton, Florida, USA.
¹⁵ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
¹⁶ Qmetrics Technologies, Rochester, NY, USA.
¹⁷ Department of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

PMID: 25952343
DOI: 10.1016/j.joca.2015.03.012

Erratum in

Osteoarthritis Cartilage. 2015 Aug; 23(8):1434-5

Abstract

Significant advances have occurred in our understanding of the pathogenesis of knee osteoarthritis (OA) and some recent trials have demonstrated the potential for modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply knee imaging in knee OA trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance (QA)/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.

Keywords: Clinical trial recommendations; Imaging; Knee osteoarthritis.

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OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis

Affiliations

OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis

Authors

Affiliations

Erratum in

Abstract

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MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical