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Case Reports
. 2015 Dec;8(4):181-4.
doi: 10.1016/j.hemonc.2015.04.003. Epub 2015 Apr 28.

inv (4)(p13q13) in patient with essential thrombocythemia: A case report

Cigdem Aydin  1 , Ozan Salim  2 , Orhan Kemal Yucel  2 , Levent Undar  2 , Sibel Berker Karauzum  3
Affiliations
Free article
Case Reports

inv (4)(p13q13) in patient with essential thrombocythemia: A case report

Cigdem Aydin et al. Hematol Oncol Stem Cell Ther. 2015 Dec.
Free article

Abstract

The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown.

Keywords: Essential thrombocythemia; Myeloproliferative disorder; inv (4)(p13q13).

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