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. 2012:2012:931528.
doi: 10.1155/2012/931528. Epub 2012 Apr 19.

Cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine

Carlos Saavedra  1 , Paola Cárdenas  1 , Héctor Castellanos  1 , Kateir Contreras  1 , J R Castro  1
Affiliations

Cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine

Carlos Saavedra et al. Case Reports Immunol. 2012.

Abstract

Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response.

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