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. 2015 Mar;9(3):SC05-7.
doi: 10.7860/JCDR/2015/10053.5683. Epub 2015 Mar 1.

Effect of vitamin d3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin d deficiency

Sakineh Mohammadian  1 , Nasrin Fatahi  2 , Hossein Zaeri  3 , Mohammad Ali Vakili  3
Affiliations

Effect of vitamin d3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin d deficiency

Sakineh Mohammadian et al. J Clin Diagn Res. 2015 Mar.

Abstract

Background: Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin.

Aims: In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency.

Materials and methods: In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD < 50 nmol/lit) treated with 300,000 units of vitamin D3. Calcium supplement (40mg/kg/day) divided in two doses in order to avoid hungry bone was also used. After three months, 25OHD and HbA1C were measured again. Differences, in mean ± SD HbA1C and 25OHD were evaluated before and after the study.

Results: Mean ± SD HbA1C was 9.73±1.85 before the study which was diminished to 8.55±1.91 after vitamin D3 supplement treatment. This decline has a significant difference (p-value < 0.0001). Mean ± SD 25OHD was 17.33±8.97 nmol/lit before the study which is increased to 39.31±14.38 nmol/lit after treatment with vitamin D3 supplement. This increase also has a significant difference (p-value < 0.0001). Vitamin D3 supplement causes the improvement of HbA1C in all groups of glycemic control including HbA1C <7.8, 7.8-9.9, and >9.9. This supplement transfer patients toward better glycemic control for the entire group (p-value < 0.0001).

Conclusion: Vitamin D3 supplement improves HbA1C in pediatrics with type I diabetes mellitus and vitamin D deficiency.

Keywords: 25OHD; Children; Glycemic changes; HbA1C.

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Figures

[Table/Fig-2]:
[Table/Fig-2]:
Comparison of glycemic control in patients with type I diabetes and vitamin D deficiency before and after interference
[Table/Fig-3]:
[Table/Fig-3]:
Comparison of 25OHD level in patients with type I diabetes and vitamin D deficiency before and after interference
See this image and copyright information in PMC

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