Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar;9(3):SM01-2.
doi: 10.7860/JCDR/2015/11960.5711. Epub 2015 Mar 1.

Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D)

Devi Dayal  1 , Madhusudan Samprati  2 , Navchetan Kaur  3 , Ranjana Walker Minz  4 , Dhaarani Jayaraman  2
Affiliations

Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D)

Devi Dayal et al. J Clin Diagn Res. 2015 Mar.

Abstract

There is wide variation in the prevalence of pancreatic and other major autoantibodies in different patient populations of Type 1 diabetes (T1D) across continents and even within countries. The data on frequency of associated autoimmunity Indian children with T1D is limited. A retrospective record review of 310 children aged 7.28±3.3 y (range 0.7-15 y) with recently diagnosed T1D attending our Pediatric Diabetes Clinic between April 2004 to September 2014, showed positivity for anti-GAD65, anti-IA2b, anti-TPO and anti-tTGA of 50% (64/128), 16% (12/72), 18.7% (23/123) and 22% (47/212) respectively. The male:female ratio in patients with anti-GAD, anti-TPO and anti-tTG positivity was 1.3, 0.7 and 0.6 respectively. In conclusion, our patient cohort exhibited a moderate prevalence of anti-GAD 65, low prevalence of anti-TPO and high prevalence of anti-tTGA autoantibodies as compared to previous reports. Male preponderance was noted in children with GAD65 positivity.

Keywords: Autoantibodies; Children; Glutamic acid decarboxylase 65; Thyroid peroxidase; Tissue transglutaminase; Type 1 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pugliese A. Advances in the etiology and mechanisms of type 1 diabetes. Discov Med. 2014;18:141–50. - PubMed
    1. Kordonouri O, Klingensmith G, Knip M, Holl RW, Aanstoot HJ, Menon PS, et al. Other complications and diabetes-associated conditions in children and adolescents. Pediatr Diabetes. 2014;15(Suppl 20):270–78. - PubMed
    1. Zimmet PZ, Rowley MJ, Mackay IR, Knowles WJ, Chen QY, Chapman LH, et al. The ethnic distribution of antibodies to glutamic acid decarboxylase: presence and levels of insulin-dependent diabetes mellitus in Europid and Asian subjects. J Diabetes Complications. 1993;7:1–7. - PubMed
    1. Singh AK, Bhatia E, Dabadghao P, Bhatia V, Gellert SA, Colman PG. Role of islet autoimmunity in the aetiology of different clinical subtypes of diabetes mellitus in young north Indians. Diabet Med. 2000;17:275–80. - PubMed
    1. Fida S, Myers M, Mackay IR, Zimmet PZ, Mohan V, Deepa R, et al. Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: Prevalence of anti-ICA512/IA2 and anti-SOX13. Diabetes Res Clin Pract. 2001;52:205–11. - PubMed

LinkOut - more resources