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Comment
. 2015 May 5;21(5):662-3.
doi: 10.1016/j.cmet.2015.04.024.

Modeling the aging heart: from local respiratory defects to global rhythm disturbances

Konstantin Khrapko  1 , Natalia Trayanova  2 , Stanley Nattel  3
Affiliations
Comment

Modeling the aging heart: from local respiratory defects to global rhythm disturbances

Konstantin Khrapko et al. Cell Metab. .

Abstract

In this issue, Baris et al. (2015) describe cardiac rhythm abnormalities in a mouse model of mitochondrial dysfunction in widely distributed cells of the aging human heart. How do a few metabolically challenged cells disrupt cardiac rhythm? We suggest that these cells provide "crystallization centers" for latent dysfunctional zones to allow arrhythmia emergence.

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References

    1. Baris OR, Ederer S, Neuhaus JFG, von Kleist-Retzow J-C, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, et al. Cell Met. 2015;21:667–677. this issue. - PubMed
    1. Carmeliet E. Physiol. Rev. 1999;79:917–1017. - PubMed
    1. Chen PS, Chen LS, Fishbein MC, Lin SF, Nattel S. Circ Res. 2014;114:1500–1515. - PMC - PubMed
    1. Chow GV, Marine JE, Fleg JL, Lin SF, Nattel S. Clin. Geriatr. Med. 2012;28:539–553. - PMC - PubMed
    1. Cooper LL, Li W, Lu Y, Centracchio J, Terentyeva R, Koren G, Terentyev D. J. Physiol. 2013;591:5895–5911. - PMC - PubMed