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Comparative Study
. 1989 Nov;165(11):824-7.

The correlation between cell survival curve and dose response curve of micronucleus (MN) frequency

K Ono  1 , E Wandl, K Tsutsui, K Sasai, M Abe
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  • PMID: 2595530
Comparative Study

The correlation between cell survival curve and dose response curve of micronucleus (MN) frequency

K Ono et al. Strahlenther Onkol. 1989 Nov.

Abstract

The correlation between cell survival curve and dose response curve of MN frequency following irradiations was studied using cytokinesis-block method. Both dose response curves were analyzed by linear quadratic model, i.e. SF = exp (-alpha D-beta D2) and MN frequency = aD + bD2 + C. A good correlation between alpha/beta and a/b ratios was observed in repeated paired experiments (= 0.97). When the cells were treated with BUdR, alpha-type radiosensitizer, a value in dose response curve of MN frequency increased but b value did not. These data present that MN frequency assay using cytokinesis-block method is available as a tool of rapid assay of radiosensitivity of cells.

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