The risk and outcomes of pneumonia in patients on inhaled corticosteroids

doi:10.1016/j.pupt.2015.04.001

Review

. 2015 Jun:32:130-6.

doi: 10.1016/j.pupt.2015.04.001. Epub 2015 May 5.

The risk and outcomes of pneumonia in patients on inhaled corticosteroids

Oriol Sibila¹, Natalia Soto-Gomez², Marcos I Restrepo³

Affiliations

¹ Servei de Pneumologia, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain; Institut d'Investigació Biomèdica Sant Pau (IBB Sant Pau), Sant Antoni Maria Claret, 167 Pavelló de Sant Frederic, Planta 1, 08025 Barcelona, Spain. Electronic address: OSibila@santpau.cat.
² South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States. Electronic address: sotogomez@uthscsa.edu.
³ South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States. Electronic address: restrepom@uthscsa.edu.

PMID: 25956073
PMCID: PMC5079105
DOI: 10.1016/j.pupt.2015.04.001

Review

The risk and outcomes of pneumonia in patients on inhaled corticosteroids

Oriol Sibila et al. Pulm Pharmacol Ther. 2015 Jun.

. 2015 Jun:32:130-6.

doi: 10.1016/j.pupt.2015.04.001. Epub 2015 May 5.

Authors

Oriol Sibila¹, Natalia Soto-Gomez², Marcos I Restrepo³

Affiliations

¹ Servei de Pneumologia, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain; Institut d'Investigació Biomèdica Sant Pau (IBB Sant Pau), Sant Antoni Maria Claret, 167 Pavelló de Sant Frederic, Planta 1, 08025 Barcelona, Spain. Electronic address: OSibila@santpau.cat.
² South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States. Electronic address: sotogomez@uthscsa.edu.
³ South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, United States; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States. Electronic address: restrepom@uthscsa.edu.

PMID: 25956073
PMCID: PMC5079105
DOI: 10.1016/j.pupt.2015.04.001

Abstract

Corticosteroids are frequently prescribed anti-inflammatory medications. Inhaled corticosteroids (ICS) are indicated for Chronic Obstructive Pulmonary Disease (COPD) and asthma. ICS are associated with a decrease in exacerbations and improved quality of life in COPD, however multiple studies have linked the chronic use of ICSs with an increased risk of developing pneumonia, though the effect on mortality is unclear. We review the association of ICS with the risk of pneumonia and the implications on clinical outcomes.

Keywords: Chronic obstructive pulmonary disease; Inhaled corticosteroids; Pneumonia.

Published by Elsevier Ltd.

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References

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[1] Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970-2002. JAMA. 2005;294:1255–1259. - PubMed

[2] Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970-2002. JAMA. 2005;294:1255–1259. - PubMed

[3] DeFrances CJ, Hall MJ, Kozak LJ. National hospital discharge survey: 2005 annual summary with detailed diagnosis and procedure data. Vital Health Stat 2007. 165:1–209. - PubMed

[4] DeFrances CJ, Hall MJ, Kozak LJ. National hospital discharge survey: 2005 annual summary with detailed diagnosis and procedure data. Vital Health Stat 2007. 165:1–209. - PubMed

[5] Heron M, Hoyert DL, Murphy SL, et al. Deaths: final data for 2006. Natl Vital Stat Rep 2009. 57:1–134. - PubMed

[6] Heron M, Hoyert DL, Murphy SL, et al. Deaths: final data for 2006. Natl Vital Stat Rep 2009. 57:1–134. - PubMed

[7] From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2011 Retrieved from http://www.ginasthma.org/

[8] From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2011 Retrieved from http://www.ginasthma.org/

[9] From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 Available from: http://www.goldcopd.org/ - PubMed

[10] From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 Available from: http://www.goldcopd.org/ - PubMed

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The risk and outcomes of pneumonia in patients on inhaled corticosteroids

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The risk and outcomes of pneumonia in patients on inhaled corticosteroids

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