Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun;4(2):128-35.
doi: 10.1530/EC-15-0034. Epub 2015 May 8.

Vitamin D, carotid intima-media thickness and bone structure in patients with type 2 diabetes

Karoline Winckler  1 , Lise Tarnow  2 , Louise Lundby-Christensen  3 , Thomas P Almdal  3 , Niels Wiinberg  4 , Pia Eiken  3 , Trine W Boesgaard  4 ; CIMT trial group
Affiliations

Vitamin D, carotid intima-media thickness and bone structure in patients with type 2 diabetes

Karoline Winckler et al. Endocr Connect. 2015 Jun.

Abstract

Despite aggressive treatment of cardiovascular disease (CVD) risk factors individuals with type 2 diabetes (T2D) still have increased risk of cardiovascular morbidity and mortality. The primary aim of this study was to examine the cross-sectional association between total (25-hydroxy vitamin D (25(OH)D)) and risk of CVD in patients with T2D. Secondary objective was to examine the association between 25(OH)D and bone health. A Danish cohort of patients with T2D participating in a randomised clinical trial were analysed. In total 415 patients (68% men, age 60±9 years (mean±s.d.), duration of diabetes 12±6 years), including 294 patients (71%) treated with insulin. Carotid intima-media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone mineral density and trabecular bone score measured by dual energy X-ray absorptiometry. In this cohort, 214 patients (52%) were vitamin D deficient (25(OH)D <50 nmol/l). Carotid IMT was 0.793±0.137 mm, DC was 0.0030±0.001 mmHg, YEM was 2354±1038 mmHg and 13 (3%) of the patients were diagnosed with osteoporosis. A 25(OH)D level was not associated with carotid IMT or arterial stiffness (P>0.3) or bone health (P>0.6) after adjustment for CVD risk factors. In conclusion, 25(OH)D status was not associated with carotid IMT, arterial stiffness or bone health in this cohort of patients with T2D. To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required.

Keywords: 25-hydroxyvitamin D; bone structure; cardiovascular disease and type 2 diabetes; carotid intima–media thickness.

PubMed Disclaimer

References

    1. Carstensen B, Kristensen JK, Ottosen P, Borch-Johnsen K, Steering Group of the National Diabetes Register The Danish National Diabetes Register: trends in incidence, prevalence and mortality. Diabetologia. 2008;51:2187–2196. doi: 10.1007/s00125-008-1156-z. - DOI - PubMed
    1. Thaulow E, Erikssen J, Sandvik L, Erikssen G, Jorgensen L, Cohn PF. Initial clinical presentation of cardiac disease in asymptomatic men with silent myocardial ischemia and angiographically documented coronary artery disease (the Oslo Ischemia Study) American Journal of Cardiology. 1993;72:629–633. doi: 10.1016/0002-9149(93)90875-D. - DOI - PubMed
    1. Schramm TK, Gislason GH, Kober L, Rasmussen S, Rasmussen JN, Abildstrom SZ, Hansen ML, Folke F, Buch P, Madsen M, et al. Diabetes patients requiring glucose-lowering therapy and nondiabetics with a prior myocardial infarction carry the same cardiovascular risk: a population study of 3.3 million people. Circulation. 2008;117:1945–1954. doi: 10.1161/CIRCULATIONAHA.107.720847. - DOI - PubMed
    1. Chambless LE, Folsom AR, Clegg LX, Sharrett AR, Shahar E, Nieto FJ, Rosamond WD, Evans G. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. American Journal of Epidemiology. 2000;151:478–487. doi: 10.1093/oxfordjournals.aje.a010233. - DOI - PubMed
    1. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK., Jr Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. New England Journal of Medicine. 1999;340:14–22. doi: 10.1056/NEJM199901073400103. - DOI - PubMed

LinkOut - more resources