Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité?
- PMID: 25956976
- DOI: 10.1016/j.biochi.2015.04.020
Non-coding transcription by RNA polymerase II in yeast: Hasard or nécessité?
Abstract
Recent developments of microarrays and deep sequencing techniques have unveiled an unexpected complexity of the eukaryotic transcriptome, demonstrating that virtualy the entire genome is transcribed by RNA polymerase II (RNAPII). Transcription occurring outside of annotated regions is generally referred to as pervasive transcription and leads to the production of several classes of non-coding RNAs (ncRNAs). In this review we will discuss the metabolism and functional significance of these ncRNAs in the yeast Saccharomyces cerevisiae. We will discuss the mechanisms that the cell has adopted to prevent potentially disruptive interference between pervasive transcription and the expression of canonical genes. We will explore the possible reasons that justify the evolutionary conserved maintenance of extensive genomic transcription.
Keywords: CPF-CF; NNS; Pervasive transcription; RNA degradation; Road-block; ncRNAs.
Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
Similar articles
-
XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast.Nature. 2011 Jun 22;475(7354):114-7. doi: 10.1038/nature10118. Nature. 2011. PMID: 21697827
-
Pervasive transcription - Lessons from yeast.Biochimie. 2011 Nov;93(11):1889-96. doi: 10.1016/j.biochi.2011.07.001. Epub 2011 Jul 12. Biochimie. 2011. PMID: 21771634 Review.
-
Roadblock termination by reb1p restricts cryptic and readthrough transcription.Mol Cell. 2014 Dec 4;56(5):667-80. doi: 10.1016/j.molcel.2014.10.026. Mol Cell. 2014. PMID: 25479637
-
Degradation of Non-coding RNAs Promotes Recycling of Termination Factors at Sites of Transcription.Cell Rep. 2020 Jul 21;32(3):107942. doi: 10.1016/j.celrep.2020.107942. Cell Rep. 2020. PMID: 32698007
-
Unexpected complexity of the budding yeast transcriptome.IUBMB Life. 2008 Dec;60(12):775-81. doi: 10.1002/iub.121. IUBMB Life. 2008. PMID: 18649367 Review.
Cited by
-
The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition.Nucleic Acids Res. 2017 Sep 29;45(17):10293-10305. doi: 10.1093/nar/gkx685. Nucleic Acids Res. 2017. PMID: 28973465 Free PMC article.
-
The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts.RNA. 2022 May;28(5):711-728. doi: 10.1261/rna.079083.121. Epub 2022 Feb 23. RNA. 2022. PMID: 35197365 Free PMC article.
-
Exogenous artificial DNA forms chromatin structure with active transcription in yeast.Sci China Life Sci. 2022 May;65(5):851-860. doi: 10.1007/s11427-021-2044-x. Epub 2021 Dec 27. Sci China Life Sci. 2022. PMID: 34970711
-
RNA-Mediated Regulation of Meiosis in Budding Yeast.Noncoding RNA. 2022 Nov 15;8(6):77. doi: 10.3390/ncrna8060077. Noncoding RNA. 2022. PMID: 36412912 Free PMC article. Review.
-
A SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage.Sci Rep. 2019 Nov 29;9(1):17914. doi: 10.1038/s41598-019-54027-y. Sci Rep. 2019. PMID: 31784551 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases