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Case Reports
. 1989 Dec;48(6):1003-6.
doi: 10.1097/00007890-198912000-00022.

Lymphoma and hypercalcemia in a pediatric orthotopic liver transplant patient

P Nakazato  1 , C O Esquivel, A H Urbach, L Makowka, V Scantlebury, R Jaffe, T E Starzl
Affiliations
Case Reports

Lymphoma and hypercalcemia in a pediatric orthotopic liver transplant patient

P Nakazato et al. Transplantation. 1989 Dec.

Abstract

We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vitamin D state, suggesting that it has a role in the pathophysiology of this B cell lymphoma hypercalcemia. The clinical course and management of this disorder with a 31-month follow-up are described.

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Figures

Figure 1
Figure 1
Immunosuppression and biochemical tests of a liver transplant recipient with lymphoproliferative disease. Note the normalization of serum calcium following debulking of the tumor. Slight elevation of the hepatic enzymes followed discontinuation of daily immunosuppression, consistent with mild rejection. (OLTX) orthotopic liver transplantation; (1) saline-Lasix therapy; (2) calcitonin therapy; (3) mithramycin therapy; (4) surgical debulking; and (5) surgical debulking.
See this image and copyright information in PMC

References

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