Haunting the HOXA Locus: Two Faces of lncRNA Regulation
- PMID: 25957895
- DOI: 10.1016/j.stem.2015.04.010
Haunting the HOXA Locus: Two Faces of lncRNA Regulation
Abstract
Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation.Cell Stem Cell. 2015 May 7;16(5):504-16. doi: 10.1016/j.stem.2015.03.007. Epub 2015 Apr 16. Cell Stem Cell. 2015. PMID: 25891907
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