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Comment
. 2015 May 7;16(5):449-50.
doi: 10.1016/j.stem.2015.04.010.

Haunting the HOXA Locus: Two Faces of lncRNA Regulation

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Haunting the HOXA Locus: Two Faces of lncRNA Regulation

Nianwei Lin et al. Cell Stem Cell. .
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Abstract

Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.

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