Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis

Abstract

Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. This article is part of a Special Issue entitled "Status Epilepticus".

Keywords: Angiogenesis; Blood–brain barrier; Epilepsy; Immune response; Inflammation; Leakage; Status epilepticus.