Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 May 11:5:9626.
doi: 10.1038/srep09626.

Histological variant as the significant predictor of survival in patients with lymph node positive urothelial carcinoma of the bladder

Hyung Suk Kim  1 , Kyung Chul Moon  2 , Chang Wook Jeong  1 , Cheol Kwak  1 , Hyeon Hoe Kim  1 , Ja Hyeon Ku  1
Affiliations

Histological variant as the significant predictor of survival in patients with lymph node positive urothelial carcinoma of the bladder

Hyung Suk Kim et al. Sci Rep. .

Abstract

The aim of this study was to evaluate the impact of histological variants of urothelial carcinoma (UC) on survival outcomes in patients with lymph node (LN) positive UC of the bladder. We reviewed and analyzed the clinical data from 424 patients who underwent radical cystectomy (RC) with pelvic lymph node dissection (PLND) for UC of the bladder and who did not receive neoadjuvant chemotherapy in our institution between 1991 and 2012. In total, 92 patients (21.7%) had histologically confirmed LN positive disease. In the LN negative group (332 patients), histological variants of UC were not a significant predictor in univariate analysis. However, in the LN positive group, histological variants of UC were a significant independent prognostic factor of overall survival (hazard ratio (HR) 3.54; 95% confidence interval (CI) 1.77-7.08, p < 0.001) and cancer specific survival (HR 3.66; 95% CI 1.69-7.90, p = 0.001) in both uni-variate and multivariate Cox regression analyses. The presence of histological variants of UC may indicate a worse prognosis in LN positive patients after RC with PLND for UC of the bladder and more aggressive adjuvant therapy may be required for the improvement of postoperative survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Kaplan-Meier curves for overall survival (A) and cancer specific survival (B) according to the presence of lymph node (LN) involvement after radical cystectomy with pelvic lymph node dissection.
Figure 2
Figure 2. Kaplan-Meier curves for overall survival (A) and cancer specific survival (B) according to the presence of histological variant of urothelial carcinoma (UC) in lymph node positive group.
See this image and copyright information in PMC

References

    1. Siegel R., Ma J., Zou Z. & Jemal A. Cancer statistics, 2014. CA Cancer J Clin 64, 9–29 (2014). - PubMed
    1. Jung K. W. et al. Prediction of cancer incidence and mortality in Korea, 2014. Cancer Res Treat 46, 124–30 (2014). - PMC - PubMed
    1. Dhar N. B. et al. Outcome after radical cystectomy with limited or extended pelvic lymph node dissection. J Urol 179, 873–8 (2008). - PubMed
    1. Stein J. P. et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19, 666–75 (2001). - PubMed
    1. Freeman J. A. et al. Radical cystectomy for high risk patients with superficial bladder cancer in the era of orthotopic urinary reconstruction. Cancer 76, 833–9 (1995). - PubMed