Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Jul;31(7):285-6.
doi: 10.1016/j.pt.2015.04.009. Epub 2015 May 7.

Rifins, rosetting, and red blood cells

Christian W Wang  1 , Lars Hviid  2
Affiliations
Comment

Rifins, rosetting, and red blood cells

Christian W Wang et al. Trends Parasitol. 2015 Jul.

Abstract

The binding of multiple uninfected erythrocytes to a central malaria parasite-infected erythrocyte (IE) is called rosetting. Rosetting has been associated with severe disease, but its functional significance,and the host receptors and parasite ligands involved are only partially known. A recent study, which describes yet another piece in this already complex puzzle, provides a welcome boost and a broadening of an important malaria research field.

Keywords: ABO blood type; PfEMP1; RIFINs; malaria; rosetting; sequestration.

PubMed Disclaimer

Comment on

  • RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.
    Goel S, Palmkvist M, Moll K, Joannin N, Lara P, Akhouri RR, Moradi N, Öjemalm K, Westman M, Angeletti D, Kjellin H, Lehtiö J, Blixt O, Ideström L, Gahmberg CG, Storry JR, Hult AK, Olsson ML, von Heijne G, Nilsson I, Wahlgren M. Goel S, et al. Nat Med. 2015 Apr;21(4):314-7. doi: 10.1038/nm.3812. Epub 2015 Mar 9. Nat Med. 2015. PMID: 25751816

LinkOut - more resources