doi: 10.1002/anie.201501812.
Epub 2015 May 8.
Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds
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- PMID: 25960013
- DOI: 10.1002/anie.201501812
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Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds
Angew Chem Int Ed Engl.
.
Abstract
A high-yielding silver(I)- or copper(II)-catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain ynone substituents, including indole, anisole, pyrrole, and benzofuran derivatives, into functionalized spirocyclic scaffolds. A high-yielding asymmetric variant furnishes spirocyclic indolenines in up to 89:11 e.r.
Keywords: asymmetric catalysis; dearomatization; indolenines; silver; spirocycles.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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