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Review
. 2015;10(1):7-11.
doi: 10.5114/pg.2014.47502. Epub 2015 Jan 14.

The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract

Marlena Brzozowa  1 , Grzegorz Wyrobiec  1 , Izabela Kołodziej  1 , Mateusz Sitarski  1 , Natalia Matysiak  1 , Edyta Reichman-Warmusz  1 , Małgorzata Żaba  1 , Romuald Wojnicz  1
Affiliations
Review

The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract

Marlena Brzozowa et al. Prz Gastroenterol. 2015.

Abstract

Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin, e.g. myofibroblasts, chondrocytes, macrophages, and endothelial cells. The expression of vimentin, which has been thought of as the main mesenchymal marker, is also detected in tumour tissue. In tumours of the gastrointestinal tract vimentin expression is usually correlated with advanced stage of tumour, lymph node metastasis, and patient survival.

Keywords: E-cadherin; gastrointestinal tumours; vimentin.

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