Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar;4(1):62-4.
doi: 10.1159/000371548. Epub 2015 Feb 18.

Rhabdomyolysis in the setting of induced hypothyroidism and statin therapy: a case report

Yaser Jbara  1 , Dean Bricker  1
Affiliations

Rhabdomyolysis in the setting of induced hypothyroidism and statin therapy: a case report

Yaser Jbara et al. Eur Thyroid J. 2015 Mar.

Abstract

Mild elevation of creatine kinase (CK) is common in untreated hypothyroidism, but severe myositis and overt rhabdomyolysis are rare. Similarly, muscle pain and CK elevation are potential side effects of statin therapy, yet rhabdomyolysis is likewise rare in the absence of medication interactions adversely affecting statin metabolism. The coexistence of statin therapy and hypothyroid states may synergistically increase the risk of myopathy. We describe a case of rhabdomyolysis attributable to induced hypothyroidism in a patient on chronic statin medication who was anticipating adjuvant radioiodine ((131)I) therapy for a thyroid carcinoma.

Keywords: Induced hypothyroidism; Recombinant human thyrotropin; Rhabdomyolysis; Statin therapy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Finsterer J, Stollberger C, Grossegger C, Kroiss A. Hypothyroid myopathy with unusually high serum creatine kinase values. Horm Res. 1999;52:205–208. - PubMed
    1. Ramadhan A, Schondorf R, Tamilia R. Rhabdomyolysis and peroneal nerve compression associated with thyroid hormone withdrawal in the setting of remnant ablation: review of the literature. Endocr Pract. 2011:17629–17635. - PubMed
    1. Lando HM, Burman KD. Two cases of statin-induced myopathy caused by induced hypothyroidism. Endocr Pract. 2008;14:726–731. - PubMed
    1. Barahona MJ, Mauri A, Sucunza N, Paredes R, Wagner AM. Hypothyroidism as a cause of rhabdomyolysis. Endocr J. 2002;49:621–623. - PubMed
    1. Ardalan MR, Ghabili K, Mirnour R, Shoja MM. Hypothyroidism-induced rhabdomyolysis and renal failure. Ren Fail. 2011;33:553–554. - PubMed