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. 2015 May;88(5):281-8.
doi: 10.4174/astr.2015.88.5.281. Epub 2015 Apr 30.

Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients

Dohern Kym  1 , Yong-Suk Cho  1 , Jaechul Yoon  1 , Haejun Yim  1 , Hyeong-Tae Yang  1
Affiliations

Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients

Dohern Kym et al. Ann Surg Treat Res. 2015 May.

Abstract

Purpose: Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI.

Methods: A total of 85 patients who were admitted to the burn intensive care unit from June 2012 to July 2013 were included in this prospective cohort study. Ten biomarkers (blood urea nitrogen, serum creatinine, urine creatinine, cystatin C, cystatin C glomerular filtration rate, AST, lacate dehydrogenase [LD], creatine kinase, lactic acid, and myoglobin) were obtained at time of admission and evaluated as diagnostic biomarkers to predicting AKI and early AKI.

Results: Out of 85 patients, 35 patients were dead and overall mortality was 41.2%. The mean age was 49.4 years and mean percentage of total body surface area was 53.2%. Area under the curve (AUC) of receiver operating characteristic curve of biomarkers on predicting AKI were 0.746, 0.718, and 0.717 in LD, lactic acid, and serum creatinine, respectively. AUC of cystatin C predicting AKI was much lower at 0.555. AUC of biomarkers on predicting early AKI were 0.833, 0.816, 0.790, and 0.759 in LD, serum creatinine, AST, and serum myoglobin.

Conclusion: LD, lactic acid and serum creatinine were acceptable as diagnostic biomarkers of AKI and LD, serum creatinine, AST, and serum myoglobin were reasonable as diagnostic biomarkers of early AKI. However, cystatin C was an unfavorable biomarker in major burn patients.

Keywords: Acute kidney injury; Biological biomarker; Burns; Cystatin C; Lactate dehydrogenase.

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Conflict of interest statement

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. The receiver operating characteristic (ROC) curves. (A) Lactate dehydrogenase (LD), lactic acid, serum creatinine, AST and serum myoblogin on diagnosis of overall acute kidney injury (AKI). (B) LD, serum creatinine, AST, serum myoglobin, lactic acid and cystatin C on diagnosis of early AKI.
See this image and copyright information in PMC

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