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. 2015 May-Jun;81(3):329-35.
doi: 10.1016/j.bjorl.2014.07.016. Epub 2015 Mar 30.

Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

Afonso Nóbrega Dantas  1 , Everton Freitas de Morais  1 , Rômulo Augusto de Paiva Macedo  1 , João Maria de Lima Tinôco  2 , Maria de Lourdes Silva de Arruda Morais  3
Affiliations

Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

Afonso Nóbrega Dantas et al. Braz J Otorhinolaryngol. 2015 May-Jun.

Abstract
in English, Portuguese

Introduction: Adenoid cystic carcinoma is the most frequent malignant tumor of the submandibular gland and the minor salivary glands. It is a malignant neoplasm that, despite its slow growth, shows an unfavorable prognosis.

Objectives: The aim of this study was to perform a systematic review of the literature on Adenoid cystic carcinoma in the head and neck region and its clinicopathological characteristics, with emphasis on the perineural invasion capacity of the tumor.

Methods: A systematic search of articles published between January 2000 and January 2014 was performed in the PubMed/MEDLINE, SciELO, Science Direct, and Scopus databases.

Results: Nine articles were selected for this systematic review. These demonstrated that the female gender was more often affected and that malignant tumors showed a high rate of distant metastasis, recurrence, and a low survival rate. The presence of perineural invasion ranged from 29.4% to 62.5% and was associated with local tumor recurrence.

Conclusion: Adenoid cystic carcinoma is commonly characterized by the presence of pain, high rate of recurrence, metastasis, and a low survival rate. Reporting studies with patient follow-up is of utmost importance for a better clinical-pathological understanding and to improve the prognosis of this pathology.

Introdução: O carcinoma adenoide cístico (CAC) é o tumor maligno mais frequente da glândula Submandibular e das glândulas salivares menores. Sendo uma neoplasia maligna, apesar de ter crescimento lento, apresenta um prognóstico desfavorável.

Objetivos: O objetivo deste trabalho foi realizar uma revisão sistemática de literatura sobre o carcinoma adenóide cístico na região de cabeça e pescoço e suas características clínico-patológicas com ênfase na capacidade de infiltração perineural do tumor.

Método: Uma busca sistemática de artigos publicados entre janeiro de 2000 a janeiro de 2014 foi executada nas bases de dados PubMed/MEDLINE, SciELO, Science Direct e Scopus.

Resultados: Nove artigos foram selecionados para realização da revisão sistemática. Nestes, o sexo feminino foi o mais afetado e o tumor maligno apresentou uma alta taxa de metástase a distância, recidiva e baixa taxa de sobrevida. A presença de invasão perineural variou entre 29,4% a 62,5% e foi relacionada à recidiva local do tumor.

Conclusão: O CAC é comumente caracterizado pela presença de dor, alta taxa de recidiva, metástase e baixa sobrevida. A realização de estudos com acompanhamento dos pacientes é de extrema importância para uma melhor avaliação clinico-patológica visando melhorar o prognóstico da doença.

Keywords: Glândulas salivares; Mouth neoplasms; Neoplasias bucais; Neoplasias das glândulas salivares; Salivary gland neoplasms; Salivary glands.

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