Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Mar-Apr;26(2 Suppl 1):S39-49.
doi: 10.5830/CVJA-2015-039.

Stroke genomics in people of African ancestry: charting new paths

R O Akinyemi  1 , B Ovbiagele  2 , A Akpalu  3 , C Jenkins, K Sagoe  3 , L Owolabi  4 , F Sarfo  5 , R Obiako  6 , M Gebreziabher  2 , E Melikam  7 , S Warth  2 , O Arulogun  7 , D Lackland  2 , A Ogunniyi  7 , H Tiwari  8 , R N Kalaria  9 , D Arnett  8 , M O Owolabi  7 ; SIREN Investigators as Members of the H3Africa Consortium
Affiliations
Review

Stroke genomics in people of African ancestry: charting new paths

R O Akinyemi et al. Cardiovasc J Afr. 2015 Mar-Apr.

Abstract

One in six people worldwide will experience a stroke in his/her lifetime. While people in Africa carry a disproportionately higher burden of poor stroke outcomes, compared to the rest of the world, the exact contribution of genomic factors to this disparity is unknown. Despite noteworthy research into stroke genomics, studies exploring the genetic contribution to stroke among populations of African ancestry in the United States are few. Furthermore, genomics data in populations living in Africa are lacking. The wide genomic variation of African populations offers a unique opportunity to identify genomic variants with causal relationships to stroke across different ethnic groups. The Stroke Investigative Research and Educational Network (SIREN), a component of the Human Health and Heredity in Africa (H3Africa) Consortium, aims to explore genomic and environmental risk factors for stroke in populations of African ancestry in West Africa and the United States. In this article, we review the literature on the genomics of stroke with particular emphasis on populations of African origin.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
SIREN component projects.
See this image and copyright information in PMC

References

    1. Lanktree MB, Dichgans M, Hegele RA. Advances in genomic analysis of stroke: what have we learned and where are we headed? Stroke. 2010;41(4):825–832. - PubMed
    1. Bevan S, Markus HS. Genetics of common polygenic ischaemic stroke: current understanding and future challenges. Stroke Res Treat 2011. 2011 179061. - PMC - PubMed
    1. Cole JW, Stine OC, Liu X, Pratap A, Cheng Y, Tallon LJ. et al. Rare variants in ischemic stroke: an exome pilot study. PLoS One. 2012;7(4) e35591. - PMC - PubMed
    1. Markus HS. Stroke genetics. Hum Mol Genet. 2011;20(R2):R124–131. - PubMed
    1. Cole JW, Brown DW, Giles WH, Stine OC, O’Connell JR, Mitchell BD. et al. Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study. Thromb J. 2008;6:11. - PMC - PubMed

Publication types

LinkOut - more resources