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Comment
. 2015 Jun;135(6):1472-1474.
doi: 10.1038/jid.2014.536.

Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages

Karyn A Haitz  1 , Niroshana Anandasabapathy  2
Affiliations
Free article
Comment

Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages

Karyn A Haitz et al. J Invest Dermatol. 2015 Jun.
Free article

Abstract

Han et al. (this issue) describe a novel mechanism by which docosahexaenoic acid (DHA) may suppress atopic dermatitis symptoms in mice. They find that DHA induces FoxP3 T regulatory cells in vivo, M2 macrophages drive transforming growth factor-β and IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macrophages suppress atopic dermatitis in mice.

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