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Comment
. 2015 May 11;27(5):609-11.
doi: 10.1016/j.ccell.2015.04.013.

Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies

Iléana Antony-Debré  1 , Ulrich Steidl  2
Affiliations
Free article
Comment

Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies

Iléana Antony-Debré et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Polprasert and colleagues identified recurrent mutations in the DEAD/H-box RNA helicase gene DDX41 in familial and acquired cases of myelodsyplasia and acute myeloid leukemia. These mutations induce defects in RNA splicing and represent a new class of mutations in myeloid malignancies.

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  • Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
    Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Müller-Tidow C, Maciejewski JP. Polprasert C, et al. Cancer Cell. 2015 May 11;27(5):658-70. doi: 10.1016/j.ccell.2015.03.017. Epub 2015 Apr 23. Cancer Cell. 2015. PMID: 25920683 Free PMC article.

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