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Multicenter Study
. 2015 Jul;71(7):861-75.
doi: 10.1007/s00228-015-1860-9. Epub 2015 May 14.

The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries

Anna Renom-Guiteras  1 , Gabriele Meyer, Petra A Thürmann
Affiliations
Multicenter Study

The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries

Anna Renom-Guiteras et al. Eur J Clin Pharmacol. 2015 Jul.

Abstract

Purpose: The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice.

Methods: A preliminary PIM list was developed, based on the German PRISCUS list of potentially inappropriate medications and other PIM lists from the USA, Canada and France. Thirty experts on geriatric prescribing from Estonia, Finland, France, the Netherlands, Spain and Sweden participated; eight experts performed a structured expansion of the list, suggesting further medications; twenty-seven experts participated in a two-round Delphi survey assessing the appropriateness of drugs and suggesting dose adjustments and therapeutic alternatives. Finally, twelve experts completed a brief final survey to decide upon issues requiring further consensus.

Results: Experts reached a consensus that 282 chemical substances or drug classes from 34 therapeutic groups are PIM for older people; some PIM are restricted to a certain dose or duration of use. The PIM list contains suggestions for dose adjustments and therapeutic alternatives.

Conclusions: The European Union (EU)(7)-PIM list is a screening tool, developed with participation of experts from seven European countries, that allows identification and comparison of PIM prescribing patterns for older people across European countries. It can also be used as a guide in clinical practice, although it does not substitute the decision-making process of individualised prescribing for older people. Further research is needed to investigate the feasibility and applicability and, finally, the clinical benefits of the newly developed list.

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Fig. 1
The development process of the EU(7)-PIM list
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References

    1. Dimitrow MS, Airaksinen MS, Kivela SL, Lyles A, Leikola SN. Comparison of prescribing criteria to evaluate the appropriateness of drug treatment in individuals aged 65 and older: a systematic review. J Am Geriatr Soc. 2011;59(8):1521–1530. doi: 10.1111/j.1532-5415.2011.03497.x. - DOI - PubMed
    1. Spinewine A, Schmader KE, Barber N, Hughes C, Lapane KL, Swine C, Hanlon JT. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370(9582):173–184. doi: 10.1016/S0140-6736(07)61091-5. - DOI - PubMed
    1. Laroche ML, Charmes JP, Merle L. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol. 2007;63(8):725–731. doi: 10.1007/s00228-007-0324-2. - DOI - PubMed
    1. Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (screening tool of older person’s prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83. doi: 10.5414/CPP46072. - DOI - PubMed
    1. Fialova D, Topinkova E, Gambassi G, Finne-Soveri H, Jonsson PV, Carpenter I, Schroll M, Onder G, Sorbye LW, Wagner C, Reissigova J, Bernabei R. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA. 2005;293(11):1348–1358. doi: 10.1001/jama.293.11.1348. - DOI - PubMed

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