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. 2016 May;8(3):197-203.
doi: 10.1093/inthealth/ihv034. Epub 2015 May 12.

Understanding of research, genetics and genetic research in a rapid ethical assessment in north west Cameroon

Jonas A Kengne-Ouafo  1 , James D Millard  2 , Theobald M Nji  3 , William F Tantoh  4 , Doris N Nyoh  5 , Nicholas Tendongfor  1 , Peter A Enyong  1 , Melanie J Newport  6 , Gail Davey  6 , Samuel Wanji  1
Affiliations

Understanding of research, genetics and genetic research in a rapid ethical assessment in north west Cameroon

Jonas A Kengne-Ouafo et al. Int Health. 2016 May.

Abstract

Background: There is limited assessment of whether research participants in low-income settings are afforded a full understanding of the meaning of medical research. There may also be particular issues with the understanding of genetic research. We used a rapid ethical assessment methodology to explore perceptions surrounding the meaning of research, genetics and genetic research in north west Cameroon.

Methods: Eleven focus group discussions (including 107 adults) and 72 in-depth interviews were conducted with various stakeholders in two health districts in north west Cameroon between February and April 2012.

Results: Most participants appreciated the role of research in generating knowledge and identified a difference between research and healthcare but gave varied explanations as to this difference. Most participants' understanding of genetics was limited to concepts of hereditary, with potential benefits limited to the level of the individual or family. Explanations based on supernatural beliefs were identified as a special issue but participants tended not to identify any other special risks with genetic research.

Conclusion: We demonstrated a variable level of understanding of research, genetics and genetic research, with implications for those carrying out genetic research in this and other low resource settings. Our study highlights the utility of rapid ethical assessment prior to complex or sensitive research.

Keywords: Cameroon; Elephantiasis; Podoconiosis; Rapid ethical assessment.

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References

    1. Lozano R, Naghavi M, Foreman K et al. . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095–128. - PMC - PubMed
    1. Murray CJ, Vos T, Lozano R et al. . Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2197–223. - PubMed
    1. Chu KM, Jayaraman S, Kyamanywa P, Ntakiyiruta G. Building research capacity in Africa: equity and global health collaborations. PLoS Med 2014;11:e1001612. - PMC - PubMed
    1. Glickman SW, McHutchison JG, Peterson ED et al. . Ethical and scientific implications of the globalization of clinical research. N Engl J Med 2009;360:816–23. - PubMed
    1. Benatar SR. Reflections and recommendations on research ethics in developing countries. Soc Sci Med 2002;54:1131–41. - PubMed