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. 2015 May;6(3):267-8.
doi: 10.1111/jdi.12273. Epub 2014 Sep 15.

Incretin action on bone: An added benefit?

Ronald C W Ma  1 , Gang Xu  2
Affiliations

Incretin action on bone: An added benefit?

Ronald C W Ma et al. J Diabetes Investig. 2015 May.
No abstract available

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Figures

Figure 1
Figure 1
Actions of glucose-dependent insulinotropic polypeptide (GIP) at its target organs. In addition to its well-known effects on pancreatic β-cell and insulin secretion, GIP has been found to have extrapancreatic effects on the brain, and enhancing memory, increasing glucose utilization in muscle, promoting lipogenesis and inflammation in adipose tissue, and increasing bone formation.
See this image and copyright information in PMC

References

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    1. Mieczkowska A, Irwin N, Flatt PR, et al. Glucose-dependent insulinotropic polypeptide (GIP) receptor deletion leads to reduced bone strength and quality. Bone. 2013;56:337–342. - PubMed
    1. Gaudin-Audrain C, Irwin N, Mansur S, et al. Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice. Bone. 2013;53:221–230. - PubMed
    1. Torekov SS, Harslof T, Rejnmark L, et al. A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk. J Clin Endocrinol Metab. 2014;99:E729–E733. - PubMed

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