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Clinical Trial
. 2015:2015:678924.
doi: 10.1155/2015/678924. Epub 2015 Mar 8.

The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

Nasser M Rizk  1 , Ayman El-Menyar  2 , Huda Egue  1 , Idil Souleman Wais  1 , Hissa Mohamed Baluli  1 , Khalid Alali  1 , Fathi Farag  3 , Noura Younes  4 , Jassim Al Suwaidi  5
Affiliations
Clinical Trial

The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients

Nasser M Rizk et al. Biomed Res Int. 2015.

Abstract

Background: Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).

Methods: We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥ 50%)).

Results: Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P = 0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P = 0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30-0.92), P = 0.038, among patients with significant stenosis.

Conclusions: Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.

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Figures

Figure 1
Figure 1
The genetic architecture of 1p13.3 and Linkage Disequilibrium (LD) of the rs599839, rs646776, and rs4970834 of on chromosomal location 1p13.3 in ACS patients. Red diamonds represent pairwise LD “EM D′” values between rs4970834 and rs646776 (upper left), rs646776 and rs599839 (upper right), and rs4970834, and rs599839 (lower), respectively.
Figure 2
Figure 2
Logistic regression analysis of the factors involved as confounding factors on the response variable of the significant lesion (≥50%) versus nonsignificant stenosis (<50%) in all ACS patients. Data are presented as odds ratio and 95% CI. Data show the effects of CVD risk factors (genetic variants (in their dominant model)) in interaction with traditional CVD risks including the following variables: old age above 60, male gender, +obesity, +DM, +hypertension, +smoker, +hyper-LDL-C above desirable level, and statin treatment on severity of significant stenosis of the coronaries in the study subjects. Two-tailed P value is significant < 0.05.
See this image and copyright information in PMC

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