Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Mar;63(3):180-6.
doi: 10.4103/0301-4738.156903.

Primary vitreoretinal lymphoma

Kaustubh Mulay, Ritesh Narula, Santosh G Honavar  1
Affiliations
Review

Primary vitreoretinal lymphoma

Kaustubh Mulay et al. Indian J Ophthalmol. 2015 Mar.

Abstract

Primary vitreoretinal lymphoma (PVRL) is an uncommon, but potentially fatal intraocular malignancy, which may occur with or without primary central nervous system lymphoma (PCNSL). Considered to be a subset of PCNSL, it is mostly of diffuse large B-cell type. The diagnosis of PVRL poses a challenge not only to the clinician, but also to the pathologist. Despite aggressive treatment with chemotherapy and/or radiotherapy, relapses or CNS involvement are common.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Fundus picture displaying a diffuse vitreous haze
Figure 2
Figure 2
Fundus picture vitreous haze with yellowish subretinal deposits and surface hemorrhages
Figure 3
Figure 3
All ill-defined yellowish grey, subretinal elevated lesion
Figure 4
Figure 4
Magnetic resonance imaging showing a homogenously enhancing solid mass lesion abutting right temporal horn of lateral ventricle and a small enhancing lesion in the left temporal lobe
Figure 5
Figure 5
Optical coherence tomography showing elevated neurosensory retina with dense subretinal shadowing
Figure 6
Figure 6
Early patchy hyperfluoresence in the area of the lesion with late leakage seen on fundus fluorescein angiography
Figure 7
Figure 7
Vitreous biopsy showing large cells with scanty to moderate cytoplasm and vesicular nuclei having prominent nucleoli (H and E, ×400)
Figure 8
Figure 8
CD20-positivity in tumor cells (CD20, ×400)
See this image and copyright information in PMC

References

    1. Mochizuki M, Singh AD. Epidemiology and clinical features of intraocular lymphoma. Ocul Immunol Inflamm. 2009;17:69–72. - PubMed
    1. Coupland SE, Damato B. Understanding intraocular lymphomas. Clin Experiment Ophthalmol. 2008;36:564–78. - PubMed
    1. Cao X, Shen D, Callanan DG, Mochizuki M, Chan CC. Diagnosis of systemic metastatic retinal lymphoma. Acta Ophthalmol. 2011;89:e149–54. - PMC - PubMed
    1. Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, et al. Primary vitreoretinal lymphoma: A report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist. 2011;16:1589–99. - PMC - PubMed
    1. Sen HN, Bodaghi B, Hoang PL, Nussenblatt R. Primary intraocular lymphoma: Diagnosis and differential diagnosis. Ocul Immunol Inflamm. 2009;17:133–41. - PMC - PubMed