Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein
- PMID: 2597138
- PMCID: PMC1133524
- DOI: 10.1042/bj2630961
Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein
Abstract
Various studies have shown that oligosaccharides play an important role in the intracellular transport and secretion of glycoproteins. We show here a difference in the rate of secretion of two mature glycoforms of a single protein, alpha 1-acid glycoprotein. This indicates the existence of kinetically different pathways for these two forms for transport from the medial Golgi to the extracellular medium.
Similar articles
-
Alpha 1-acid glycoprotein (orosomucoid): pathophysiological changes in glycosylation in relation to its function.Glycoconj J. 1995 Jun;12(3):227-33. doi: 10.1007/BF00731324. Glycoconj J. 1995. PMID: 7496136 Review.
-
Differential secretion of alpha 1-acid glycoprotein occurs in the Golgi complex of isolated rat hepatocytes. Evidence of partial retention in the Golgi.Eur J Biochem. 1994 Feb 1;219(3):1073-9. doi: 10.1111/j.1432-1033.1994.tb18590.x. Eur J Biochem. 1994. PMID: 8112320
-
Effect of the threonine analog beta-hydroxynorvaline on the glycosylation and secretion of alpha 1-acid glycoprotein by rat hepatocytes.J Biol Chem. 1985 Sep 5;260(19):10847-55. J Biol Chem. 1985. PMID: 3928623
-
Increased affinity to concanavalin A and enhanced secretion of alpha 1-acid glycoprotein by hepatocytes isolated from turpentine-treated rats.Eur J Cell Biol. 1989 Oct;50(1):111-6. Eur J Cell Biol. 1989. PMID: 2612498
-
Anti-inflammatory properties of specific glycoforms of human alpha1-acid glycoprotein.Adv Exp Med Biol. 2003;535:251-6. doi: 10.1007/978-1-4615-0065-0_16. Adv Exp Med Biol. 2003. PMID: 14714900 Review. No abstract available.
Cited by
-
Alpha 1-acid glycoprotein (orosomucoid): pathophysiological changes in glycosylation in relation to its function.Glycoconj J. 1995 Jun;12(3):227-33. doi: 10.1007/BF00731324. Glycoconj J. 1995. PMID: 7496136 Review.
-
Changes in serum glycoprotein glycosylation during experimental inflammation in mice are general, unrelated to protein type, and opposite changes in man and rat: studies on mouse serum alpha 1-acid glycoprotein, alpha 1-esterase, and alpha 1-protease inhibitor.Inflammation. 1992 Dec;16(6):631-44. doi: 10.1007/BF00919346. Inflammation. 1992. PMID: 1459696
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources