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. 2016 Aug;16(3):307-16.
doi: 10.1007/s10238-015-0355-4. Epub 2015 May 14.

miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor

Xianjuan Shen  1 , Yuehua Guo  2 , Jiajia Yu  3 , Jing Qi  1 , Wei Shi  1 , Xinhua Wu  1 , Hongbing Ni  4 , Shaoqing Ju  5   6   7
Affiliations

miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor

Xianjuan Shen et al. Clin Exp Med. 2016 Aug.

Abstract

Bone marrow stromal cells (BMSCs) up-regulate B cell-activating factor (BAFF) in multiple myeloma. Increasing experimental evidence has shown that microRNAs play a causal role in hematology tumorigenesis. In this study, we characterized the role of miR-202 in regulating the expression of BAFF in BMSCs. It was found that expressions of BAFF mRNA and protein were increased in BMSCs treated with miR-202 inhibitor. The growth rate of miR-202 mimics transfection cells was significantly lower than that of non-transfected cells. The expression of Bcl-2 protein was down-regulated, and Bax protein was up-regulated after miR-202 mimics transfection. Over-expression of miR-202 in BMSCs rendered MM cells more sensitive to bortezomib. More significantly, the regulatory effect of miR-202 could inhibit the activation of NF-κB pathway in BMSCs. These results suggest that miR-202 functions as a modulator that can negatively regulate BAFF by inhibiting MM cell survival, growth, and adhesion in the bone marrow microenvironment.

Keywords: B cell-activating factor (BAFF); Bone marrow stromal cells (BMSCs); Drug resistance; Multiple myeloma (MM); microRNA-202 (miR-202).

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