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. 2015 Jul;22(7):836-9.
doi: 10.1128/CVI.00193-15. Epub 2015 May 13.

Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease

Rhonda L LaFleur  1 , Steven M Callister  2 , Jennifer C Dant  1 , Terri L Wasmoen  1 , Dean A Jobe  3 , Steven D Lovrich  3
Affiliations

Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease

Rhonda L LaFleur et al. Clin Vaccine Immunol. 2015 Jul.

Abstract

Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.

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