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Multicenter Study
. 2015 Jul;53(7):2365-7.
doi: 10.1128/JCM.01085-15. Epub 2015 May 13.

Detection of Group A Streptococcus in Pharyngeal Swab Specimens by Use of the AmpliVue GAS Isothermal Helicase-Dependent Amplification Assay

Matthew L Faron  1 , Nathan A Ledeboer  1 , Paul Granato  2 , Judy A Daly  3 , Kristina Pierce  4 , Preeti Pancholi  5 , Timothy S Uphoff  6 , Blake W Buchan  7
Affiliations
Multicenter Study

Detection of Group A Streptococcus in Pharyngeal Swab Specimens by Use of the AmpliVue GAS Isothermal Helicase-Dependent Amplification Assay

Matthew L Faron et al. J Clin Microbiol. 2015 Jul.

Abstract

We evaluated the clinical performance (sensitivity and specificity) of the AmpliVue group A Streptococcus (GAS) isothermal helicase-dependent amplification assay using 1,192 pharyngeal swab specimens. AmpliVue GAS assay results were compared to the results of routine throat cultures on selective streptococcal blood agar plates. The sensitivity and specificity of the AmpliVue GAS assay were 98.3% (95% confidence interval [CI], 95 to 100%) and 93.2% (95% CI, 91 to 95%), respectively.

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