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Review
. 2015 Feb 3:12:4.
doi: 10.1186/1743-7075-12-4. eCollection 2015.

Pros and cons of CLA consumption: an insight from clinical evidences

Sailas Benjamin  1 , Priji Prakasan  1 , Sajith Sreedharan  1 , Andre-Denis G Wright  2 , Friedrich Spener  3
Affiliations
Review

Pros and cons of CLA consumption: an insight from clinical evidences

Sailas Benjamin et al. Nutr Metab (Lond). .

Abstract

This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.

Keywords: CLA; Clinical evidences; Conjugated linoleic acids; Review.

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Figures

Figure 1
Figure 1
Major ω fatty acids with their common names, structures and systemic names.
Figure 2
Figure 2
Proposed effects of CLA consumption on heart health.
See this image and copyright information in PMC

References

    1. Bauman D, Baumgard L, Corl B, Griinari JM. Biosynthesis of conjugated linoleic acid in ruminants. Proc Am Soc of Anim Sci. 1999;77:1–15.
    1. Bauman D, Corl B, Peterson D. Advances in Conjugated Linoleic Acid Research. Vol.2. 2. Champaign, USA: AOC Press; 2003. The biology of conjugated linoleic acids in in ruminants; pp. 146–73.
    1. Griinari J, Corl B, Lacy S, Chouinard PY, Nurmela KVV, Bauman DE. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Δ9-desaturase. J Nutr. 2000;130(9):2285–91. - PubMed
    1. Turpeinen AM, Mutanen M, Aro A, Salminen I, Basu S, Palmquist DL, et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. Am J Clin Nutr. 2002;76(3):504–10. - PubMed
    1. Kuhnt K, Flotho S, Benjamin S, Boerchers T, Schubert R, Jahreis G, et al. Gene expression after dietary intervention with trans fatty acids (trans‒11/trans‒12 18: 1) in humans. Eur J Lipid Sci Technol. 2009;111(5):442–50.