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. 2015 Mar-Apr;41(2):133-42.
doi: 10.1590/S1806-37132015000004367.

Assessment of quality of life in patients with advanced non-small cell lung carcinoma treated with a combination of carboplatin and paclitaxel

Camila Uanne Resende Avelino  1 , Rafael Marques Cardoso  2 , Suzana Sales de Aguiar  3 , Mário Jorge Sobreira da Silva  4
Affiliations

Assessment of quality of life in patients with advanced non-small cell lung carcinoma treated with a combination of carboplatin and paclitaxel

Camila Uanne Resende Avelino et al. J Bras Pneumol. 2015 Mar-Apr.

Abstract

Objective: Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. Most patients are diagnosed at an advanced stage, palliative chemotherapy therefore being the only treatment option. This study was aimed at evaluating the health-related quality of life (HRQoL) of advanced-stage NSCLC patients receiving palliative chemotherapy with carboplatin and paclitaxel.

Methods: This was a multiple case study of advanced-stage NSCLC outpatients receiving chemotherapy at a public hospital in Rio de Janeiro, Brazil. The European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire was used in conjunction with its supplemental lung cancer-specific module in order to assess HRQoL.

Results: Physical and cognitive functioning scale scores differed significantly among chemotherapy cycles, indicating improved and worsened HRQoL, respectively. The differences regarding the scores for pain, loss of appetite, chest pain, and arm/shoulder pain indicated improved HRQoL.

Conclusions: Chemotherapy was found to improve certain aspects of HRQoL in patients with advanced-stage NSCLC.

Keywords: Carboplatin; Carcinoma, non-small-cell lung; Paclitaxel; Palliative care; Quality of life.

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Figures

Figure 1 -
Figure 1 -. Changes in mean European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) functional scale scores. In A, differences in mean EORTC QLQ-C30 scores between the 1st and 2nd cycles of chemotherapy (n = 16); in B, differences in mean EORTC QLQ-C30 scores between the 2nd and 4th cycles of chemotherapy (n = 13); and in C, differences in mean EORTC QLQ-C30 scores between the 1st and 4th cycles of chemotherapy (n = 13). QoL: quality of life.
Figure 2 -
Figure 2 -. Changes in mean European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) symptom scores. In A, differences in mean EORTC QLQ-C30 scores between the 1st and 2nd cycles of chemotherapy (n = 16); in B, differences in mean EORTC QLQ-C30 scores between the 2nd and 4th cycles of chemotherapy (n = 13); and in C, differences in mean EORTC QLQ-C30 scores between the 1st and 4th cycles of chemotherapy (n = 13).
Figure 3 -
Figure 3 -. Changes in mean European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire supplemental lung cancer-specific module (EORTC QLQ-LC13) scores. In A, differences in mean EORTC QLQ-LC13 scores between the 1st and 2nd cycles of chemotherapy (n = 16); in B, differences in mean EORTC QLQ-LC13 scores between the 2nd and 4th cycles of chemotherapy (n = 13); and in C, differences in mean EORTC QLQ-LC13 scores between the 1st and 4th cycles of chemotherapy (n = 13).
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