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. 2015 Feb 1;8(2):1804-9.
eCollection 2015.

Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer

Binmei Xiao  1 , Zhiyi Xie  1 , Lan Guo  1 , Jianchi Wu  1 , Hongwen Zhang  2
Affiliations

Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer

Binmei Xiao et al. Int J Clin Exp Pathol. .

Abstract

Aims: To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer.

Methods: The expression of STOML2 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Immunohistochemistry was performed to evaluation of STOML2 expression in 94 paraffin-embedded cervical cancer samples. The correlation between STOML2 expression and cervical cancer progression and prognosis was analyzed statistically.

Results: STOML2 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Of the 94 cervical cancer cases, high STOML2 expression was detected in 54 cases (57.4%). STOML2 expression was significantly related to tumor stage (P = 0.013) and tumor size (P = 0.025). Moreover, patients with high expression of STOML2 had a significant shorter overall survival and recurrent free survival time compared with those with low STOML2 expression in cervical cancer (P = 0.001 and P = 0.017, respectively). Multivariate analysis revealed that STOML2 was an independent prognostic factor (P = 0.022) for the overall survival in cervical cancer.

Conclusion: Our study showed STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer.

Keywords: STOML2; cervical cancer; overall survival; recurrent free survival.

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Figures

Figure 1
Figure 1
Real time-PCR analysis of STOML2 expression in each of the cervical cancer and paired adjacent normal cervical tissues, asterisks, P < 0.05.
Figure 2
Figure 2
Representative images of STOML2 from immunohistochemistry assays in cervical cancer specimens (high expression for A, and low expression for B) 400 ×.
Figure 3
Figure 3
Kaplan-Meier curves of overall survival (A) and recurrent free survival (B) in relation to STOML2 expression in 94 cervical cancer patients.
See this image and copyright information in PMC

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