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Review
. 2015 Feb 1;8(2):1826-9.
eCollection 2015.

Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature

Song Mao  1 , Xiaoyan Xuan  1 , Yugen Sha  1 , Sanlong Zhao  1 , Aihua Zhang  1 , Songming Huang  1
Affiliations
Review

Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature

Song Mao et al. Int J Clin Exp Pathol. .

Abstract

An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine. The complete clinical remission was achieved after 9 months. No serious adverse effects were observed during the follow-up. Our findings indicated that CPAGN with isolated C3 deposition might have a favorable prognosis after aggressive immunosuppressive treatment. However, the influence of isolated C3 deposition on CPAGN prognosis remains to be clarified.

Keywords: C3; Crescentic poststreptococcal acute glomerulonephritis; deposition.

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Figures

Figure 1
Figure 1
Glomeruli with endocapillary proliferation with cellular crescents (light microscopy, PAS staining).
Figure 2
Figure 2
Immunofluorescence findings with intense mesangium deposits of C3.
Figure 3
Figure 3
subepithelial deposition of electron dense material (Electro-microscopy).
See this image and copyright information in PMC

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