Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Feb 1;8(2):1826-9.
eCollection 2015.

Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature

Song Mao  1 , Xiaoyan Xuan  1 , Yugen Sha  1 , Sanlong Zhao  1 , Aihua Zhang  1 , Songming Huang  1
Affiliations
Review

Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature

Song Mao et al. Int J Clin Exp Pathol. .

Abstract

An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine. The complete clinical remission was achieved after 9 months. No serious adverse effects were observed during the follow-up. Our findings indicated that CPAGN with isolated C3 deposition might have a favorable prognosis after aggressive immunosuppressive treatment. However, the influence of isolated C3 deposition on CPAGN prognosis remains to be clarified.

Keywords: C3; Crescentic poststreptococcal acute glomerulonephritis; deposition.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Glomeruli with endocapillary proliferation with cellular crescents (light microscopy, PAS staining).
Figure 2
Figure 2
Immunofluorescence findings with intense mesangium deposits of C3.
Figure 3
Figure 3
subepithelial deposition of electron dense material (Electro-microscopy).
See this image and copyright information in PMC

References

    1. Gale DP, Maxwell PH. C3 glomerulonephritis and CFHR5 nephropathy. Nephrol Dial Transplant. 2013;28:282–8. - PubMed
    1. Xiao X, Pickering MC, Smith RJ. C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis. Semin Thromb Hemost. 2014;40:465–71. - PubMed
    1. Abrera-Abeleda MA, Nishimura C, Frees K, Jones M, Maga T, Katz LM, Zhang Y, Smith RJ. Allelic variants of complement genes associated with dense deposit disease. J Am Soc Nephrol. 2011;22:1551–1559. - PMC - PubMed
    1. Elfenbein IB, Baluarte HJ, Cubillos-Rojas M, Gruskin AB, Coté M, Cornfeld D. Quantitative morphometry of glomerulonephritis with crescents. Diagnostic and predictive value. Lab Invest. 1975;32:56–64. - PubMed
    1. Ma R, Cui Z, Hu SY, Jia XY, Yang R, Zheng X, Ao J, Liu G, Liao YH, Zhao MH. The alternative pathway of complement activation may be involved in the renal damage of human anti-glomerular basement membrane disease. PLoS One. 2014;9:e91250. - PMC - PubMed

MeSH terms