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. 2015 Feb 1;8(2):1946-53.
eCollection 2015.

Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance

Yongli Chen  1 , Chuanqi Chen  2 , Chengzhi Ma  2 , Shibo Sun  2 , Jing Zhang  2 , Yan Sun  2
Affiliations

Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance

Yongli Chen et al. Int J Clin Exp Pathol. .

Abstract

Purpose: To detect the expression and prognostic clinical significance of heat-shock protein gp96 (HSP gp96) in gallbladder cancer.

Methods: Immunohistochemistry was used to detect and compare the rate of HSP gp96 expression in 107 samples of gallbladder cancer, 70 of gallbladder adenoma and 67 of chronic cholecystitis. The association of clinicopathological factors and patients' survival were calculated by univariate and multivariate (Cox proportional hazard regression method) analysis.

Results: The expression positive rate of HSP gp96 was 90.7% (97/107) in gallbladder cancer, 71.4% (50/70) in gallbladder adenoma and 47.76% (32/67) in chronic cholecystitis respectively. The positive rate of HSP gp96 in gallbladder cancer tissues was significantly higher than that in gallbladder adenoma and chronic cholecystitis tissues (P < 0.01). Multivariate and Cox regression analysis showed that positive of HSP gp96 (P = 0.026) expression was an independent poor prognostic predictor in gallbladder cancer.

Conclusions: HSP gp96-positive expression is closely correlated with poor survival in gallbladder cancer.

Keywords: HSP gp96; chronic cholecystitis; gallbladder adenoma; gallbladder cancer.

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Figures

Figure 1
Figure 1
Positive expression of gp96 in gallbladder cancer (A), gallbladder adenoma (B) and chronic cholecystitis (C) (original magnification IHC ×200).
Figure 2
Figure 2
The survival rate was calculated by the Kaplan-Meier method according to gp96 (A), gender (B), lymph node metastasis (C), gall stone (D), degree of differentiation (E), T stage (F), age (G), the statistically significant prognostic factors was gp96 (A), lymph node metastasis (C), degree of differentiation (E), T stage (F).
See this image and copyright information in PMC

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