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Case Reports
. 2015 Feb 1;8(2):2074-8.
eCollection 2015.

CT-guided needle biopsy in the diagnosis of lung adenocarcinoma accompanied by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a rare combination

Panwen Tian  1 , Ye Wang  1 , Chun Wan  1 , Yongchun Shen  1 , Fuqiang Wen  1
Affiliations
Case Reports

CT-guided needle biopsy in the diagnosis of lung adenocarcinoma accompanied by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a rare combination

Panwen Tian et al. Int J Clin Exp Pathol. .

Abstract

We represent a rare case of lung adenocarcinoma accompanied by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). The patient was a 66-year-old male presented with 1 month history of recurrent cough and hemoptysis. Chest CT showed solitary ground-glass opacity (GGO) in the upper lobe of the right lung and mediastinal lymph node enlargement in station 3p. A CT-guided transthoracic needle biopsy was performed. Tissue specimens of the GGO revealed a typical adenocarcinoma. Histopathologic diagnosis of mediastinal lymph node was extranodal marginal zone lymphoma of MALT. Because of its rarity, extranodal marginal zone lymphoma of MALT should be considered in the differential diagnosis when we encounter mediastinal lymphadenopathy in patients with lung adenocarcinoma.

Keywords: CT-guided needle biopsy; Lung adenocarcinoma; lymphoma; mucosa-associated lymphoid tissue.

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Figures

Figure 1
Figure 1
A GGO in the upper lobe of the right lung (arrow).
Figure 2
Figure 2
Mediastinal lymph node enlargement in station 3p (arrow).
Figure 3
Figure 3
CT-guided transthoracic needle biopsy of the lung.
Figure 4
Figure 4
Histopathologic examination (400×) of the GGO in the lung reveals adenocarcinoma.
Figure 5
Figure 5
CT-guided transthoracic needle biopsy of a mediastinal lymph node.
Figure 6
Figure 6
Histopathologic examination (400×) of the mediastinal lymph node. A. Infiltration of small atypical cells resembling centrocyte-like lymphocytes. Immunohistochemically, these lymphocytes were positive for B. CD20 and negative for C. CD5. Ki-67 labeling index D. Was approximately 10%.
See this image and copyright information in PMC

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