Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015;3(2):183-192.
doi: 10.1007/s40139-015-0077-z.

Key Fibrogenic Signaling

Weichun He  1 , Chunsun Dai  1
Affiliations
Review

Key Fibrogenic Signaling

Weichun He et al. Curr Pathobiol Rep. 2015.

Abstract

Fibrosis is defined as an excessive accumulation of extracellular matrix components that lead to the destruction of organ architecture and impairment of organ function. Moreover, fibrosis is an intricate process attributable to a variety of interlaced fibrogenic signals and intrinsic mechanisms of activation of myofibroblasts. Being the dominant matrix-producing cells in organ fibrosis, myofibroblasts may be differentiated from various types of precursor cells. Identification of the signal pathways that play a key role in the pathogenesis of fibrotic diseases may suggest potential therapeutic targets. Here, we emphasize several intracellular signaling pathways that control the activation of myofibroblasts and matrix production.

Keywords: Fibrosis; Mitogen-activated protein kinase; Phosphoinositide 3 kinase; Smad; Sonic hedgehog; Wnt/β-catenin.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. •• Wynn TA, Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 18:1028–1040. The authors discuss how key components of the innate and adaptive immune response contribute to the pathogenesis of fibrosis - PMC - PubMed
    1. Lam AP, Gottardi CJ. Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol. 2011;23:562–567. doi: 10.1097/BOR.0b013e32834b3309. - DOI - PMC - PubMed
    1. •• Zeisberg M, Kalluri R (2013) Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol 304:C216–C225. This review focuses on common and organ-specific pathways of tissue fibrosis - PMC - PubMed
    1. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-beta signaling in fibrosis. Growth Factors. 2011;29:196–202. doi: 10.3109/08977194.2011.595714. - DOI - PMC - PubMed
    1. •• Liu Y (2011) Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 7:684–696. Renal fibrogenesis is a dynamic process that can be divided into four overlapping phases—priming, activation, execution, and progression—in which many of these events occur concomitantly - PMC - PubMed

LinkOut - more resources