Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Aug;34(8):903-5.
doi: 10.1097/INF.0000000000000757.

Urine Collection Method for the Diagnosis of Congenital Cytomegalovirus Infection

Shannon A Ross  1 , Amina Ahmed, April L Palmer, Marian G Michaels, Pablo J Sánchez, Audra Stewart, David I Bernstein, Kristina Feja, Zdenek Novak, Karen B Fowler, Suresh B Boppana; National Institute on Deafness and Other Communication Disorders CHIMES Study
Affiliations

Urine Collection Method for the Diagnosis of Congenital Cytomegalovirus Infection

Shannon A Ross et al. Pediatr Infect Dis J. 2015 Aug.

Abstract

Congenital cytomegalovirus infection is traditionally diagnosed by virus detection in saliva or urine. Virus culture was positive in significantly fewer urine samples collected using cotton balls in diapers (55.2%) than with samples collected by bags (93.2%) from newborns screened positive for CMV in saliva. However, polymerase chain reaction was positive in 95% of urine samples regardless of the collection method.

PubMed Disclaimer

Conflict of interest statement

Author Disclosures: The authors have no relevant conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Results of urine testing by rapid culture or PCR for the diagnosis of congenital CMV infection by collection method.
See this image and copyright information in PMC

Comment in

References

    1. Britt W. Cytomegalovirus. In: Remington JS, Klein JO, Wilson CB, Baker CJ, editors. Infectious Diseases of the Fetus and Newborn Infant. 7th. Philadelphia: W.B. Saunders Company; 2011. pp. 704–753.
    1. Dahle AJ, Fowler KB, Wright JD, Boppana SB, Britt WJ, Pass RF. Longitudinal investigations of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol. 2000;11:283–290. - PubMed
    1. Boppana SB, Ross SA, Novak Z, et al. Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA. 2010;303:1375–1382. - PMC - PubMed
    1. Boppana SB, Ross SA, Shimamura M, et al. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011;364:2111–2118. - PMC - PubMed
    1. Boppana SB, Smith R, Stagno S, Britt WJ. Evaluation of a microtiter plate fluorescent antibody assay for rapid detection of human cytomegalovirus infections. J Clin Microbiol. 1992;30:721–723. - PMC - PubMed

Publication types