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. 2015 May 26;313(20):2019-20.
doi: 10.1001/jama.2015.2544.

Optogenetics and the circuit dynamics of psychiatric disease

Karl Deisseroth  1 , Amit Etkin  2 , Robert C Malenka  2
Affiliations

Optogenetics and the circuit dynamics of psychiatric disease

Karl Deisseroth et al. JAMA. .
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: No other disclosures were reported.

Figures

Figure
Figure. Steps in Optogenetic Research
Diverse opsin genes from microbes are engineered in the laboratory to allow light-activated regulation of ion flow and biochemical pathways. Targeted opsins allow cell-specific control with light with precision not achievable by electrodes. Mice can be implanted with fiberoptics that can both deliver optogenetic control and collect fluorescent readout of neural activity with fiber photometry. At left, black trace shows neuronal membrane voltage; blue ticks show pulses of light driving ChR2 to elicit action potentials (spikes in the membrane voltage); and yellow bar shows steady light providing inhibition of the neuron through NpHR. At right, red ticks indicate rewarding sucrose solution ingestion; black trace shows corresponding elevations in deep brain dopamine neuron activity.
See this image and copyright information in PMC

References

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