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Review
. 2015 May 15;22(1):32.
doi: 10.1186/s12929-015-0140-4.

Cytochrome P450 in living donor liver transplantation

King-Wah Chiu  1 , Toshiaki Nakano  2 , Kuang-Den Chen  2 , Li-Wen Hsu  2 , Chia-Yun Lai  2 , Ching-Yin Huang  2 , Yu-Fan Cheng  2 , Shigeru Goto  2 , Chao-Long Chen  2
Affiliations
Review

Cytochrome P450 in living donor liver transplantation

King-Wah Chiu et al. J Biomed Sci. .

Abstract

Cytochrome P450 metabolizes many drugs in the liver. Three genotypes of CYP2C19 with extensive, intermediate, and poor metabolizing activity, respectively, have been identified in peripheral blood of transplant recipients and new liver grafts in living donor liver transplantation (LDLT). The expression of the final genotype in liver graft biopsies depends on the donor, whereas the expression in peripheral blood mononuclear cells depends on the recipient. The metabolizing isoenzyme of the major anti-rejection agents passes through CYP3A4, CYP3A5 and MDR1, which have also been identified to have similar biological characteristics as genotype of CYP2C19 in liver tissue. Recently, pyrosequencing has been used to investigate the expressions of different genotypes in liver grafts in LDLT. This review focuses on recent findings regarding the biological expressions of the CYP2C19, CYP3A4, CYP3A5 and MRD1 genotypes in liver grafts before and after LDLT. The application of pyrosequencing may be beneficial in further research on liver transplantation. Laser capture microdissection of hepatocytes in liver grafts may be a direction for future research.

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Figures

Fig. 1
Fig. 1
Picture of the homogenous phenomenon arising from the different genotypes of CYP2C19, CYP3A4, CYP3A5 and MDR1 between the donor and recipient in the cytochrome P450 system after living donor liver transplantation. The homogenous phenomenon is representing with the recipient blood (green block) go in the liver graft (white color) but the black ground of cytochrome P450 is still remain their own characteristic of isoenzymes even the recipient blood go through the graft
See this image and copyright information in PMC

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