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Editorial
. 2015 May 19;65(19):2067-9.
doi: 10.1016/j.jacc.2015.03.519.

Myocardial Infarct Scar: Hunting Down the Responsible Cells, But Then What?

Megan Monsanto  1 , Mark A Sussman  2
Affiliations
Editorial

Myocardial Infarct Scar: Hunting Down the Responsible Cells, But Then What?

Megan Monsanto et al. J Am Coll Cardiol. .
No abstract available

Keywords: cardiac fibroblast; epicardium-derived cell; infarct scar.

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Figures

figure 1
figure 1. Origin of Cardiac Fibroblasts
Current opinion is that most cardiac fibroblasts originate from the bone marrow, endothelium, and/or the epicardium following myocardial infarction (MI). The study performed by Ruiz-Villalba et al. (1) identifies epicardium-derived cells (EPDCs) as the main source of cardiac fibroblasts following acute infarction. At embryonic day (E) 15.5, epithelial cells lining the epicardium migrate to the myocardial interstitial space. The undifferentiated EPDCs become activated cardiac fibroblasts upon myocardial injury.
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References

    1. Ruiz-Villalba A, Simón AM, Pogontke C, et al. Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells from myocardial infarction scar. J Am Coll Cardiol 2015; 65:2057–66. - PubMed
    1. Lajiness JD, Conway SJ. Origin, development, and differentiation of cardiac fibroblasts. J Mol Cell Cardiol 2014;70:2–8. - PMC - PubMed
    1. Souders CA, Bowers SLK, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res 2009;105: 1164–76. - PMC - PubMed
    1. Zeisberg EM, KaLLuri R. Origins of cardiac fibroblasts. Circ Res 2011;107:1304–12. - PMC - PubMed
    1. Díaz-Flores L, Gutiérrez R, Madrid JF, et al. Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 2009;24:909–69. - PubMed