[Association between CYP1A1 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China]

Abstract

Objective: To assess the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) among the Uygur population of China.

Methods: Genotypes of CYP1A1 single nucleotide polymorphisms (SNPs: rs4886605, rs12441817, rs4646422 and rs1048943) were detected by real-time PCR in 293 CAD patients and 408 controls.

Results: Among the Uygur group, distribution of genotypes and allele of rs4886605 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (CC vs. CT+TT) of rs4886605 was significantly lower among CAD patients than in controls. Significant differences were retained after the adjustment was made in all the participants (OR = 0.368, 95% CI: 0.185-0.530, P = 0.018) and in men (OR = 0.350, 95% CI: 0.235-0.568, P = 0.015). Distributions of genotypes and allele of rs12441817 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (TT vs. CT+CC) of rs12441817 was significantly lower among patients CAD than in controls. Significant difference were retained after the adjustment was made, in total participants (OR = 0.253, 95% CI: 0.231-0.546, P = 0.016) and in men (OR = 0.241, 95% CI: 0.132-0.478, P = 0.002).

Conclusion: Both rs4886605 and rs12441817 SNPs of the CYP1A1 gene were associated with CAD in the Uygur population of China.