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Comment
. 2014;8(4):232-3.
doi: 10.1080/19336934.2015.1039756.

An expression system for Gustatory receptors - and why it failed

Hubert Amrein  1
Affiliations
Comment

An expression system for Gustatory receptors - and why it failed

Hubert Amrein. Fly (Austin). 2014.

Abstract

A recent paper by the Dahankuar laboratory suggested that single Drosophila sugar receptors proteins accurately mediate sugar detection when ectopically expressed in olfactory neurons of the antenna. These findings contra-dict numerous previously published electrophysiological and behavioral investigations, which all point towards heteromultimeric sugar taste receptors. Here, I provide some explanation why this "pseudo-heterologous" expression system may have led to this misleading conclusion.

Keywords: Gr Genes; expression system; heterodimers; olfactony learning and memory; olfactory neuron; taste receptors.

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References

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