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Observational Study
. 2015 Oct;43(5):561-7.
doi: 10.1007/s15010-015-0794-6. Epub 2015 May 15.

Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease

Micaela Brandolini  1 , Marta Corbella  1   2 , Annalisa De Silvestri  2 , Carmine Tinelli  1 , Giulia Albonico  3 , Riccardo Albertini  3 , Serena Ludovisi  4 , Raffaele Bruno  5 , Piero Marone  1 , Lorenzo Minoli  4 , Elena Seminari  6
Affiliations
Observational Study

Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease

Micaela Brandolini et al. Infection. 2015 Oct.

Abstract

Observational retrospective study to evaluate the etiology, the outcome and the risk factors of bloodstream infections (BSIs) in patients with liver disease. One hundred and forty-eight BSIs were diagnosed (infection rate: 0.60 per 100 days of hospital stay), 62 BSIs (41.9 %) were associated with Gram-positive bacteria (infection rate: 0.25 per 100 days of hospital stay) and 80 (54.4 %) with Gram-negative bacteria (infection rate: 0.32 per 100 days of hospital stay). Admission-associated mortality was higher in patients with BSI than in those without BSI (20.6 versus 5.0 %, p < 0.001). Patients with cirrhosis had an increased risk to develop a BSI compared with patients with chronic hepatitis, specifically for Gram-positive (and Staphylococcus spp)-related BSI.

Keywords: Bloodstream infection; Chronic hepatitis; Liver cirrhosis.

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