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. 2015 Aug 15;61(4):619-22.
doi: 10.1093/cid/civ386. Epub 2015 May 14.

PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Agnieszka Wójtowicz  1 , T Doco Lecompte  2 , Stephanie Bibert  1 , Oriol Manuel  3 , Sina Rüeger  4 , Christoph Berger  5 , Katia Boggian  6 , Alexia Cusini  7 , Christian Garzoni  8 , Hans Hirsch  9 , Nina Khanna  9 , Nicolas J Mueller  10 , Pascal R Meylan  11 , Manuel Pascual  12 , Christian van Delden  2 , Pierre-Yves Bochud  1 ; Swiss Transplant Cohort Study
Collaborators, Affiliations
Free article

PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Agnieszka Wójtowicz et al. Clin Infect Dis. .
Free article

Abstract

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.

Keywords: PTX3; SNP; genetic susceptibility; innate immunity; solid organ transplant.

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Comment in

  • PTX3-Based Genetic Testing for Risk of Aspergillosis After Lung Transplant.
    Cunha C, Monteiro AA, Oliveira-Coelho A, Kühne J, Rodrigues F, Sasaki SD, Schio SM, Camargo JJ, Mantovani A, Carvalho A, Pasqualotto AC. Cunha C, et al. Clin Infect Dis. 2015 Dec 15;61(12):1893-4. doi: 10.1093/cid/civ679. Epub 2015 Aug 10. Clin Infect Dis. 2015. PMID: 26261201 No abstract available.
  • Reply to Cunha et al.
    Wójtowicz A, Lecompte TD, Bibert S, Manuel O, Rüeger S, Berger C, Boggian K, Cusini A, Garzoni C, Khanna N, Mueller NJ, Meylan PR, Pascual M, van Delden C, Bochud PY; Swiss Transplant Cohort Study. Wójtowicz A, et al. Clin Infect Dis. 2015 Dec 15;61(12):1894-5. doi: 10.1093/cid/civ681. Epub 2015 Aug 10. Clin Infect Dis. 2015. PMID: 26261206 No abstract available.

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